What is the significance of balanced levels of dNTPs during DNA synthesis? (I th

Question

What is the significance of balanced levels of dNTPs during DNA synthesis? (I think its C, but not sure) A.) An excess of one of the dNTPs is likely to inhibit DNA repair mechanisms. B.) An excess of one of the dNTPs is likely to inhibit synthesis of RNA primers. C.) A single dNTP at high levels is more likely to be misincorporated, while a single dNTP at very low levels is more likely to be replaced by another during DNA synthesis. D.) An excess of one of the dNTPs is likely to inhibit 3' -> 5' exonuclease activity.

Match each of the following:

Match each of the following: Replicons Telomeres Telomerase G-quartet Proliferating cell nuclear antigen 1. Forms a ring structure and complexes with DNA polymerase delta 2. l he ends of eukaryotic chromosomes 3. Four-stranded, guanine-rich telomeric structure 4. DNA segments in eukaryotic chromosomes that are served by a replication origin 5. Ribonucleoprotein that synthesizes telomeric DNA

Explanation / Answer

high levels of dNTP is detrimental to the fidelity of DNA replication.this reflects the propensity of DNA polymerase to extend a mismatched primer-template and reduced proofreading at high nucleotide levels.

hence answer to the first question is c

replicons-4

telomeres-2

telomerase-5

G quartet-3

proliferating cell uclear antigen-1

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