Assume that the sequence below has experienced a spontaneous mutation resulting

Question

Assume that the sequence below has experienced a spontaneous
mutation resulting in the tautomeric forms of all of the bases. Further assume that this shifted sequence serves as a template in replication. Write the new sequence of the complementary strand as a result of this shift and identify the type of substitution (if any) for each base on new complementary strand compared to the original complementary strand.


Sequence (5’ TO 3’)
CGGTGTGACACTAGGTAGTCTAACGAGCTCACGGGCAGGGCTATATGTTGCAAAGTCGTAGGTCAC

Complementary sequence (3’ TO 5’)
GCCACACTGTGATCCATCAGATTGCTCGAGTGCCCGTCCGATATACAACGTTTCAGCATCCAGTG

Explanation / Answer

The original template strand is: CGG TGT GAC ACT AGG TAG TCT AAC GAG CTC ACG GGC AGG GCT ATA TGT TGC AAA GTC GTA GGT CAC The mutated template is: TAA CAC AGT GTC GAA CGA CTC GGT AGA TCT GTA AAT GAA ATC GCG CAC CAT GGG ACT ACG AAC TGT Due to tautomerism, A binds with G and C binds with T. The mutated new complementary strand is: ATT GTG TCA CAG CTT GCT GAG CCA TCT AGA CAT TTA CTT TAG CGC GTG GTA CCC TGA TGC TTG ACA The type of substituition is transition as A is converted to G and C is converted to T.

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