Calculate In humans (37 degree C) the enzyme alcohol dehydrogenase (ADH) is a ho

Question

Calculate

In humans (37 degree C) the enzyme alcohol dehydrogenase (ADH) is a homodimer with a large hydrophobic inter-subunit contact region. The formation of a quaternary structure for ADH is a reversible process. Suppose the enzyme dissociates according to the equation: dimer 2 monomer Delta G = 12 Kcal/mol Calculate the concentration of monomer and dimer present at equilibrium if the initial concentration of ADH dimer was 1 times 10-6 M prior to any dissociation to single subunits. (hint: you will first need to use Delta G = -RT Keq)

Explanation / Answer

12 kcal/mol= -1.987 x 10^-3 x 310 x Keq

Keq = 19.48

concentration of monomer is 19.48 times that of dimer at equilibrium

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