Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (7TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 270 G? subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 30 ATP molecules to cAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer to at least two significant figures

Explanation / Answer

270 x 30 = 8100 molecules/sec

(8100molecules/sec) x (1 mol/ 6.022x10^23) = 1.345x10^-20

rounded to 2 sig figs: 1.3x10^-20

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