antibodies with different polypeptides sequence are generated by an unusual mech

Question

antibodies with different polypeptides sequence are generated by an unusual mechanism in which individual antibody genes are spliced together by ____________

the intervening region between v and j domains is removed during antibody gene development when the DNA strand is digested and then reconnected in a process known as ________

options to chose from: homologous recombination, antibody, recombinanse , recombination signal sequence, antigen, nonhomologous en-joining (NHEJ), signal peptide, site-specific recombination.

Explanation / Answer

antibodies with different polypeptides sequence are generated by an unusual mechanism in which individual antibody genes are spliced together by Recombinase.

the intervening region between v and j domains is removed during antibody gene development when the DNA strand is digested and then reconnected in a process known as nonhomologous en-joining (NHEJ).

NHEJ plays a critical role in V(D)J recombination but unlike typical cellular NHEJ where the purpose is to perform an accurate repair, error-prone repair in V(D)J recombination creates maximum diversity in the coding sequence of these genes and thus prove to be beneficial. This process assembles "variable" (V), "diversity" (D), and "joining" (J) regions creating the variable region of a B-cell or T-cell receptor gene.

Explanation: Maintaining the antigen binding diversity is critical to recognize different pathogens. This is maintained by the presence of variable and constant regions on the same polypeptide chain and identical V regions used with different C regions. Ig genes are randomly spliced together from gene segments that allow many V regions to be used with a few C regions. During B cell development, recombinase enzymes remove introns and some exons from the DNA and splice segments into functional Ig genes.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.