biology multiple choice help 6. Which structure in RNA polymerase ll plays a rol

Question

biology multiple choice help

6. Which structure in RNA polymerase ll plays a role in translocation, the movement of RNA polymerase to the next nucleotide of the DNA template? A, Bridge Funnel C Lid D. Rudder 7. How does TBP bind to the TATA box? As a homodimer B. As a heterodimer Certain amino acids in the DNA binding domain form hydrogen bonds to acceptors and donors of the minor groove D. Certain amino acids in TBP bind to nucleotides of the major groove of the TATA box. E. TBP binds to TAF1, which binds to the promoter. 8. Which of RNA polymerase transcri on factor is a kinase fol a and a helicase that aids in promoter clearance? A TFIIB B. TFIID C, TFIIE D. TFIIH E TF1IS

Explanation / Answer

Ques-6:

Answer: A. bridge

Reason:

Pre-initiation complex formed by TBP in the eukaryotic DNA (A- T rich TATA box absent) 35 nitrogen bases upstream followed by DNA melting due to formation of negatively charged bonding with DNA backbone using arginine and lysine amino acid residues of TBP. In this manner DNA –TBP protein interaction promotes transcription-using type II RNA polymerase using other transcription factors such as SL1, TFIIB, TFIIC, and TFIID. These factors mainly control the gene expression through the process of transcription when generating messenger RNA in the presence of RNA polymerase. The binding site of RNAP also controls the amount of transcription.

Bridge helix is the structure that promotes translocation RNA polymerase II (RNAP-II) in which, the movement of RNA polymerase with DNA-RNA complex & promote sliding of RNAP- II the next nucleotide of the DNA template instead of dissociation. Therefore, bridge helix in the complex acts as a molecular rachet to promote forward translocation of RNAP to bind to next base during transcription

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