When the channel is open, what provides the driving force for ion transport ? Is
ID: 8023 • Letter: W
Question
When the channel is open, what provides the driving force for ion transport ?
Is this in any way correct or am I missing a few things?
Open ion channels provoke rapid responses. Ions are driven though channels by the sum of their chemical (concentration) gradient and their electrical potential gradient. The concentration gradient is simply the difference in concentration of an ion inside and outside the cell. Sodium, for example, is chemically driven into the cell because it is much more concentrated in the extracellular fluid, while potassium is driven out of the cell because it is concentrated in the cell.
The electrical gradient is determined by the charge of an ion and by the voltage difference across the cell membrane. Sodium and potassium are both positively charged, so they are driven into the cell because there is a buildup of negative charge on the internal surface of the membrane. (Important to note that the net charge in the cell and out are neutral and that the membrane potential is only a change in the distribution of charge up against the cell membrane).
The net flux flow for a given ion, is determined by the net driving force, which is the sum mentioned above, times the permeability of the channel to that particular ion. Permeability is determined by the abundance of non-gated channels for the specific ion.
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