1. Of the different drugs discussed in this experiment, which should have the gr
ID: 804984 • Letter: 1
Question
1. Of the different drugs discussed in this experiment, which should have the greatest Rf value with a nonpolar developing solvent and why?
-Acetaminophen, because the amine and alcohol groups found on the structure have very little polarity
-Caffeine, because all polar groups are evenly distributed around the central structure
-Ibuprofen, because although it has a carboxylic acid functional group this is only a small part of the entire structure which is nonpolar in nature
-Naproxen, because it is nonpolar
2. Which error is most likely to have caused the following scenario: the solvent does not flow evenly up the slide and the result is a distorted chromatogram with overlapping spots and/or spots off the side of the plate
-The spots are placed too close together
-When placing spots the applicator dislodged some of the adsorbent
-An incorrect developing solvent was used
-The plate was developed at the incorrect temperature
3. Ingredient labels for many drugs also give the systematic name for the active ingredient. Another correct name for acetominophen would be:
-p-acetylaminophenol
-2(4-isobutylphenyl)-propanoic acid
-acetylsalicyclic acid
-2-hydroxybenzamide
Explanation / Answer
1))Ibruprofen because although it has a carboxylic acid functional group this is only a small part of the entire structure which is nonpolar in nature.
2)when placing spots the applicator dislodged some of the adsorbent
3)acetylsalicyclic acid
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