One molecular change that has been associated with aging is methylation of DNA.
ID: 80568 • Letter: O
Question
One molecular change that has been associated with aging is methylation of DNA. From the list below, select all of the statements regarding DNA methylation that are TRUE (select ALL that apply).
Select one or more:
a. People who live to be over 100 years old tend to be epigenetically younger than their chronological age
b. DNA methylation increases at some genetic locations and decreases at other locations as people age
c. DNA methylation increases throughout DNA as people age
d. Biological age can be estimated from levels of DNA methylation
e. All organs accumulate changes in DNA methylation at the same rate
f. DNA methylation is a type of mutation - it changes DNA sequences
g. DNA methylation decreases throughout as people age
h. DNA methylation is a type of epigenetic modification
Explanation / Answer
Ans: a, b, d, g and h are correct.
Epigenetic clocks indicate that the offspring are about 5 years anger biological e than other people of the same chronological age.
Some tissues have greater methylation for example many promoters of tumor suppressor genes show higher levels of methylation suggesting possible connection with age associated increases in Cancer risk.
DNA relation declines with age.
Some studies demonstrated that DNA methylation age is highly heritable measure of an acceleration which is close to zero for embryonic and induced pluripotent stem cells. In the future DNA methylation age could be used to assess and individuals risk for age related diseases and their treatment could be tailored based on the biological DNA methylation age instead of the actual chronological age.
DNA methylation take place primary in non mitotic cell. It makes sure that a muscle cell expresses only genes important to muscle function by permanently turning off gens that are used in other types of cells.
DNA methylation is an epi genetic mechanism commonly used by cells to control gene expression.
Genomic Global DNA methylation decreases with age.
Epigenetic changes alter the physical structure of DNA an example of epigenetic changes is DNA methylation- in which methyl group is added to the DNA molecule preventing certain genes from being expressed.
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