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The Ras protein functions as a molecular switch that is set to its on state by o

ID: 8071 • Letter: T

Question

The Ras protein functions as a molecular switch that is set to its on state by other proteins that cause it to bind GTP. A GTPase-activating protein resets the switch to the off state by inducing Ras to hydrolyze its bound GTP to GDP much more rapidly that it would without this encouragement. Thus Ras works like a light switch that one person turns on and another turns off. You are given a mutant cell that lacks the GTPase-activating protein. What abnormalities would you expect to find in the way that Ras activity responds to extracellular signals?

Explanation / Answer

If there is no reset switch (GTPase-activating protein) it will be hydolyzing GTP to GDP much longer meaning extracellular signals could be ignored depending on the strenght what the signal is telling the Ras to do.

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