When does the hemoglobin concentration of the blood increase or decrease? What i
ID: 81023 • Letter: W
Question
When does the hemoglobin concentration of the blood increase or decrease? What is the function of RBCs? When does RBC count increase or decrease? What is the function WBCs? When does WBC count increase or decrease? What is the function of platelets? When does the platelets count increase or decrease? What indicated when MCV increases or decreases? What is indicated when MCH increases or decreases? What is indicated when MCHC increases or decreases? What is the difference between blood plasma & serum? When does packed cell volume increase or decrease? Which factors affect the accuracy of the test of RBC osmotic fragility? Which factors affect the osmotic fragility of RBCs?Explanation / Answer
ANSWER:
1) A low MCHC can be interpreted as identifying decreased production of hemoglobin. MCHC can be normal even when hemoglobin production is decreased (such as in iron deficiency) due to a calculation artifact. MCHC can be elevated in hereditary spherocytosis, sickle cell disease and homozygous haemoglobin C disease, depending upon the hemocytometer.
2) The most important function of red blood cells is the transport of oxygen (O2) to the tissues. The hemoglobin absorbs oxygen in the lungs. Then it travels through blood vessels and brings oxygen to all other cells via the heart.
A relatively stable number of RBCs is maintained in the circulation by increasing or decreasing the rate of production by the bone marrow. Some conditions affect RBC production and may cause an increase or decrease in the number of mature RBCs released into the bloodcirculation.
3) In addition to the irregularly shaped leukocytes, both red blood cells and many small disc-shaped platelets are visible. White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
Certain respiratory illnesses, such as whooping cough or tuberculosis may cause the levels of white blood cells to increase. In some cases, all white blood cells are affected. However, some people have a specific disease in which only one type of white blood cell is affected.
4) The principal function of platelets is to prevent bleeding. Red blood cells are the most numerous blood cell, about 5,000,000 per microliter.These limits, however, are determined by the 2.5th lower and upper percentile, and a deviation does not necessary imply any form of disease.
5) It is a variation of the MCV measurement. The MCH is increased in and decreased in the same conditions as the MCV. The average hemoglobin concentration per unit volume (100 ml) of packed red cells is indicated by MCHC. MCHC is increased in and decreased in the same conditions as the MCV.
6) It can be spuriously increased in autoagglutination and hyperlipidemia due to spuriously low hematocrit and spuriously high Hb, respectively. Truly increased MCHC usually occurs in hereditary spherocytosis or in some cases of homozygous sickle cell or hemoglobin C disease.
7) A low MCHC can be interpreted as identifying decreased production of hemoglobin. MCHC can be normal even when hemoglobin production is decreased due to a calculation artifact. MCHC can be elevated in hereditary spherocytosis, sickle cell disease and homozygous haemoglobin C disease, depending upon the hemocytometer.MCHC can be elevated in some megaloblastic anemias. MCHC can be artifactually elevated when there is agglutination of red cells or when there is opacifaction of the plasma .
8) Serum is that part of blood which is similar in composition with plasma but exclude clotting factors ofblood. Fibrinogen is a protein that is involved in bloodcoagulation. Fibrinogen is an inactive protein and it performs its functions by converting into fibrin.
9) In large vessels with low hematocrit, viscosity dramatically drops and red cells take in a lot of energy. While in smaller vessels at the micro-circulation scale, viscosity is very high. With the increase in shear stress at the wall, a lot of energy is used to move cells.
10) It is a test that measures the resistance to hemolysis of red blood cells exposed to hypotonic solutions.RBC are exposed to a series of saline solutions with increasing dilution .The sooner hemolysis occurs , the greater is osmotic fragility of RBC.
11) Temperature, pH, preincubation in plasma, and proteolytic digestion all affected Duchenne and normal cells to the same extent.
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