Here are two different ways to make the precursor for 2,4-D from benzene. Lable
ID: 822961 • Letter: H
Question
Here are two different ways to make the precursor for 2,4-D from benzene. Lable each of the following reactions as electrophilic aromatic substitution (EAS), Nucleophilic aromatic substitution (NAS), Interfunctional group conversion (IC) protection (P), Deprotection (D), Sandmeyer, Kolbe, or Claisen Rearrangment. For the NAS reactions, determine it as either addidtion-elimination or elimination-addition.
I have most of it filled out and need to double check. thanks.
Explanation / Answer
A= Nucleophilic aromatic substitution (NAS)
B= Protection (P)
C= electrophilic aromatic substitution (EAS)
D= Deprotection (D)
E= electrophilic aromatic substitution (EAS)
F= electrophilic aromatic substitution (EAS)
G= Nucleophilic aromatic substitution (NAS)
H= Interfunctional group conversion (IC)
I & J = Sandmeyer (The substitution of an aromatic amino group via preparation of its diazonium salt and subsequent displacement with a nucleophile (Cl-, I-, CN-, RS-, HO- called sandmeyer reaction (http://en.wikipedia.org/wiki/Sandmeyer_reaction))
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