What would be the predicted results, during DNA replication, of a mutation in th
ID: 85095 • Letter: W
Question
What would be the predicted results, during DNA replication, of a mutation in the genes encoding telomerase?
a. chromosomes would be fail to attach to the mitotic spindle and be lost during cell division
b. chromosomes would break and bridge during mitosis
c. chromosomes would gradually become shorter with each cell division
d. a mutation in telomerase would have no effect on DNA replication
An individual carries a chromosome anomaly that leads to the following phenotypes: Production of gametes containing duplications and deletions, gametes with chromosomes that bridge and break during meiosis, and loss of chromosomes during meiosis. What is the most likely chromosomal aberration in this case?
a. Balanced translocation
b. Paracentric inversion
c. Pericentric inversion
d. Aneuploidy
How much of the 6,500 nucleotide long CTFR mRNA comprises the 5’ and 3’ untranslated regions (UTRs)? (Remember, UTRs are sequences present in the mRNA but not translated into polypeptide.)
a. 2060 nucleotides
b. 4440 nucleotides
c. 244 kilobases
d. None of the mRNA is untranslated
Explanation / Answer
What would be the predicted results, during DNA replication, of a mutation in the genes encoding telomerase?
Ans: b. chromosomes would break and bridge during mitosis.
Cell lacking telomerase undergo chromosomal aberration.
An individual carries a chromosome anomaly that leads to the following phenotypes: Production of gametes containing duplications and deletions, gametes with chromosomes that bridge and break during meiosis, and loss of chromosomes during meiosis. What is the most likely chromosomal aberration in this case?
d. Aneuploidy
Aneuploidy is the presence of an abnormal number of chromosomes in a cell. Where genes may be deleted, duplicated, undergo loss of chromosome etc.
How much of the 6,500 nucleotide long CTFR mRNA comprises the 5’ and 3’ untranslated regions (UTRs)? (Remember, UTRs are sequences present in the mRNA but not translated into polypeptide.)
a. 2060 nucleotides.
Size of CFTR protein is 1480 aa. So at least 4440 nucleotides must be coded for aa to produce this protein . Then the rest part is UTR
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