Human hemoglobin alpha subunit was cleaved to fragments by two different methods

Question

Human hemoglobin alpha subunit was cleaved to fragments by two different methods A and B. After sequencing by Edman degradation, the primary sequences of the fragments were determined (shown below). What methods were used to fragment the protein? Determine the full sequence of alpha subunit of hemoglobin.

Human hemoglobin alpha subunit was cleaved to fragments by two different methods A and B. After sequencing by Edman degradation, the primary sequences of the fragments were determined (shown below). What methods were used to fragment the protein? Determine the full sequence of alpha subunit of hemoglobin.

Human hemoglobin alpha subunit was cleaved to fragments by two different methods A and B. After sequencing by Edman degradation, the primary sequences of the fragments were determined (shown below). What methods were used to fragment the protein? Determine the full sequence of alpha subunit of hemoglobin.

Explanation / Answer

(Line 2A) MVLSPADKTN VKAAWGKVGA HAGE --> (Line 4A) YGAE --> (Line 5A)ALE --> (Line 1A) RMFLSFPTT KTYFPHFDLS HGSAQVKGHG KKVADALTNAVAHVDDMPNA LSALSDLHAH KLRVDPVNFK LLSHCLLVTLAAHLPAE --> (Line3A) FTPAVHASLDKFL ASVSTVLTSK YR

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