Normally there are channel proteins that allow passage of the ions, but in patie
ID: 85931 • Letter: N
Question
Normally there are channel proteins that allow passage of the ions, but in patients with one kind of CF these proteins seem odd. Closer examination shows that these proteins display the correct aminoacid sequence; however they fail to do their job. Which of the following is the most likely cause of the malfunctioning of these proteins given that their aminoacid sequence is correct?
a. A mutation in a chaperone protein
b. The protein got denatured
c. The DNA has the incorrect sequence
d. A mutation in the ion channel protein
e. There is a problem with one of the aminoacids
Explanation / Answer
Q: Normally there are channel proteins that allow passage of the ions, but in patients with one kind of CF these proteins seem odd. Closer examination shows that these proteins display the correct aminoacid sequence; however they fail to do their job. Which of the following is the most likely cause of the malfunctioning of these proteins given that their aminoacid sequence is correct?
a. A mutation in a chaperone protein - Correct Answer
b. The protein got denatured
c. The DNA has the incorrect sequence
d. A mutation in the ion channel protein
e. There is a problem with one of the aminoacids
Explanation: Since it is mentioned that the amino acid sequence of the ion channel proteins is correct, therefore one of the possibilities of malfunction of these channel proteins could be because of improper functioning of a specific chaperon caused due to a mutation in chaperone gene. A normally functional chaperone assists channel proteins fold and function properly by directly interacting with them. A mutation in chaperone could adversely impact and restrict their functionality thereby leading to misappropriate folding of channel proteins rendering them dysfunctional.
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