Immediately following the birth of a baby girl, the attending physician requeste
ID: 86338 • Letter: I
Question
Immediately following the birth of a baby girl, the attending physician requested a protein electrophoretic examination of the mother’s serum. This was done on a sample that was obtained on the mother’s admission to the hospital the previous day. An electrophoretic examination was also performed on the cord-blood specimen. Laboratory reports are shown in the following chart. The appearance of the mother’s electrophoretic pattern was within that expected for a healthy person.
ELECTROPHORESIS VALUES (G/DL)
ADULT
REFERENCE MOTHER’S CORD
VALUES SERUM BLOOD
Albumin 3.5–5.0 4.2 3.3
1-Globulins 0.1–0.4 0.3 0.0
2-Globulins 0.3–0.8 1. 2 0.4
-Globulins 0.6–1.1 1.3 0.7
-Globulins 0.5–1.7 1.3 1.0
1. What protein fraction(s) is/are abnormal in the mother’s serum and the cord blood serum?
2. An abnormality in this/these fraction(s) is/are most often associated with what disease?
3. What other test(s) may be done to confirm this abnormality?
Explanation / Answer
Answer:
Abnormal levels of any group of serum proteins can be determined by electrophoresis. It separates globulins into the alpha-1, alpha-2, beta and gamma fractions.
1.From the above lab report, the protein fractions in the mother's serum are nearly coming the within that expected for a healthy person. But 2 fractions shows a slight deviation
The abnormal protein fractions in the cord blood is
2. The disease associated with the abnormal fractions:
Mother's serum:
Cord blood:
3. In cold blood, alpha-1-antitrypsin deficiency can be further diagnosed by A1AT blood test.
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