Explain the molecular basis for cystic learned in lecture for chapter 15. Name t

Question

Explain the molecular basis for cystic learned in lecture for chapter 15. Name two proteins found in the light Actin-binding proteins bind to actin and modify its properties. You purify a protein. C&p1;, that seems so bind and cap one end of an actin filament, although you do not know whether it binds the plus end or the end. To determine which end of the actin filament your protein binds to, you decide to examine the effect of Capl on actin polymerization by measuring the kinetics of actin filament formation in the presence and the of Capl protein. You the following results (see figure below). Do you think Capl binds the and or the minus end of actin? Explain your reasoning.

Explanation / Answer

Ans C3- Translation on the ribosomes along the rough endoplasmic reticulum (RER) results in the formation of two alpha chains, that is, alpha-1 and alpha-2 chains, which are also known as preprocollagen. They have registration peptides on each end and a signal peptide. Then, the Polypeptide chains are released into the lumen of the Rough Endoplasmic Reticulum.The chains are then known as pro-alpha chains after the signal peptides are cleaved inside the RER and they are transported to the Golgi apparatus within tubular structures. Hydroxylation of lysine and proline amino acids along with the Glycosylation of specific hydroxylysine residues occurs. Triple alpha helical structure is formed inside the endoplasmic reticulum from two alpha-1 chains and one alpha-2 chain within spherical distensions present along the saccules on the cis side of Golgi stacks. The spherical distensions lengthen into cylindrical ones and become part of the saccules on the trans-side of Golgi stacks.
Procollagen is released from trans-saccules and shipped to the Golgi apparatus. It is then packaged and secreted by exocytosis while some procollagen material finds way into lysosomes.The released procollagen is then transformed into collagen.

Loss of collagen can affect the effective transport of blood throughout the entire body as it gives the vessels strength, structure and flexibility.
Loss of Collagen fibers can also affect the strength and structure of the muscles needed to move and function throughout the day.

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