Complete the sentences to describe the effect of a mutated CFTR channel on patie

Question

Complete the sentences to describe the effect of a mutated CFTR channel on patients with cystic fibrosis. The CFTR channels in cells that line the respiratory tract move ____ ions out of the cell. The movement of this ion causes ___ to follow. The resulting compound of NaCl creates an osmotic pull that ____ water to the outside of the cell. The __ in water in the respiratory tract helps to ___ mucus that is naturally found lining the tract. In patients with cystic fibrosis, the CFTR channel is malfunctioning, preventing movement of. The effect is a (n) __ in water movement out of the cell and, therefore, a ___ mucus. The resulting mucus is harder to move, and thus causes blockages in the narrow lung passages.

Explanation / Answer

The CFTR channels in cells that line the respiratory tract move Cl- ions out of the cell. The movement of this ion causes the Na+ to follow. The resulting compound of NaCl creates an osmotic pull that attracts water to the outside of the cell. The increase in water in the respiratory tract helps to thin mucus that is naturally found lining the tract. In patients with cystic fibrosis, the CFTR channel is malfunctioning, preventing movement of Cl-ions. The effect is a(n) decrease in water movement out of the cell and therefore,a thicker mucus. The resulting mucus is harder to move and thus causes blockages in the narrow lung passages.

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