Explain why superficial skin scrape(such as a paper cut) doesn\'t bled. Why don\

Question

Explain why superficial skin scrape(such as a paper cut) doesn't bled. Why don't you bleed when a cut? Shampoos and hair conditions often claim to have nutrients vitamins your hair must have to grow and healthy. Taking into accounts the composition of hair do you think these vitamins and nutrients will be Why or why not? Many drugs can be applied to the skin without entering the blood. Hoe is this fat explained by the structure skin? The disease bullous pemphigoid results in the destruction of proteins within the basement membrane that hole epidermis and dermis together. How would this likely affect the epidermis? Would the skin be an effective this disease? Would you have expected to have found more Meissner's corpuscles and Merkel disks on the palm or on the posterior shoulder? Why?

Explanation / Answer

Answer:

1. Both injuries involve the epidermis, which is avascular.

2. Hair consists of dead cells, and dead cells don’t grow, need nutrients, or need vitamins.

3. The stratum corneum is made up of layers of overlapping cell plates containing the fibrous protein keratin. Most drug absorption is transcellular and is unlikely that noticeable absorption occurs between cells or through sweat pores and hair follicles. It is a passive diffusion process, the magnitude of which depend upon the integrity nad efficacy of the epidermal barrier but which will be influenced by the drug itself.

4. Bullous pemphigoid (BP) is a blistering disease characterized by inflammatory infiltrate in the dermis and the presence of IgG and C3 deposits along the basement membrane zoneand circulating IgG autoantibodies. Autoantibodies bound to autoantigens, the glycoproteins BPAG1 (230 kD) and BPAG2 (180 kD), localized in the basement membrane of the epidermis activate a series of immunological and enzymatic phenomena leading to the destruction of basement membrane components and the formation of blisters.

The main physical barrier is the epidermis. The dermis contains all the nerve endings and hair follicles. When you get a blister, the affected skin area fills with water. While the blister is still protective, it is technically disconnected from the dermis layer.

5. We would expect to find more on the palm because this part of the body requires greater nerve sensitivity.

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