(b). In terms of bond enthalpies, why do you suppose most decarboxylation reacti
ID: 891780 • Letter: #
Question
(b). In terms of bond enthalpies, why do you suppose most decarboxylation reactions are exergonic?(HINT: most decarboxylation reactions are NOT coupled to ATP hydrolysis)
(c)Given your answer above, why would ATP hydrolysis need to be coupled to this reaction? Or state another way, what are the cellular consequences of coupling ATP hydrolysis to this decarboxylation? Sketch a full labelled reaction coordinate diagram (potential energy diagram) for the decarboxylation reaction in the absence and presence of ATP.
0 Mevalonate 5-diphosphate o ATP+ Mg* ADP+CO P Isopentenyl DiphosphateExplanation / Answer
a. No, it is a decarboxylase as it is MDD; EC 4.1.1.33 but it is a coupled rxn and need as substrates ATP and Mevalonate 5-diphosphate.
b. As an exergonic rxn is linked to a rxn which is sponteneous it means that energy is released as heat. This might be explain because the C=O bonds are bonds with a high bonding energy.
c. This rxn might be coupled with ATP hydrolysis due to the released energy. The cellular consequense of coupling ATP hydrolysis to this decarboxylation is the formation of ADP which is used as coenzyme in other process.
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