Ask c) and d) My answer for a) is 1.56%. I think the answer for c) is same. Is t

Question

Ask c) and d) My answer for a) is 1.56%. I think the answer for c) is same. Is that right? ANSWER QUESTIONS 1, 2 AND 3 IN ONE BooK Aa Question 1 I 18 marks /18 minutesl I In the pedigree to the right, allele a is a rare, autosomal recessive, disease-causing allele. The II genotypes of individuals I.1 and L2 are given. a) Calculate the probability that individual IV.1 will show the disease. Asume that penetrance of the disease genotype is complete. Explain your answer. [6 marks] b) Redraw this pedigree to show the likely IV genotypes of all individuals for the situation where individual IV.1 shows the disease. (4 marks] c) Using the original pedigree, calculate the probability that individual IV.1 will show the disease if the a allele is dominant. Asume that penetrance of the disease genotype is complete. Explain your answer. [6 marks] d) Based on your answer to part (c), calculate the probability that individual IV.1 will show the disease if the penetrance of the disease genotype is 50% 12 marks]

Explanation / Answer

yes, the answer for A) and C) is the same.

a)Probability that individual will show the disease is 1.5 and is the same for c)

d) Probability that the individual will show the disease if the disease penetrance is 50% is 0.25 because the probability that the parent is carrier 1/2 and probabiltity that the child inherits that allele form the parent is 1/2

1/2 * 1/2 = 1/4

Thus, 0.25

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