Which of the following changes would occur in the HPG axis if you castrated an a

Question

Which of the following changes would occur in the HPG axis if you castrated an adult man? Check all correct options for full credit.

Select one or more:

a. Testosterone release would decrease

b. GnRH release would increase

c. Testosterone release would increase

d. GnRH release would decrease

e. LH release would increase

f. LH release would decrease

Which of the following changes would take place if you removed the anterior pituitary of a man?

Select one or more:

a. Testosterone release would decrease

b. GnRH release would increase

c. FSH release would decrease

d. Testosterone release would increase

e. FSH release would increase

f. GnRH release would decrease

Release of which of the following hormones would INCREASE if you blocked inhibin release? Check all correct options for full credit.

Select one or more:

a. Testosterone

b. FSH

c. DHT

d. GnRH

e. LH

Development of which of the following tissues in an embryo is affected by DHT levels? Check all correct options for full credit.

Select one or more:

a. Mullerian ducts

b. Gonads

c. Urogenital sinus

d. Genital tubercle

e. Wolffian ducts

Which of the following would not develop in a manner typical of male fetuses if there was a mutation in 5alpha-reductase? Check all correct options for full credit.

Select one or more:

a. Peniss

b. Scrotumss

c. Epididymis

d. Vas deferens

e. Prostate gland

f. Testes

Explanation / Answer

(1) HPG Axis refers to the Hypothalamus-pituitary-gonadal axis in which hypothalamus, pituitary, and gonads act synchronously as a single system. AS we know that in castration only testicles will be removed therefore only Testosterone secretion will be affected.

therefore, in this case, testosterone secretion would decrease because of removal of testicles and there would not be any effect on secretion of GnRH and (LH, FSH) which are secreted by Hypothalamus and pituitary respectively.

(2) As already mentioned in part1 that anterior pituitary secrete LH and FSH, therefore, removal of it would decrease secretion of LH and FSH and their corresponding functions in males

(3) FSH secretion will increase as inhibin inhibit the secretion of FSH

(4) DHT has an important role in the development of male external genitalia, therefore, it will control genital tubercle development.

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