Given the following molecules and their pKa values, answer the following and bri

ID: 920523 • Letter: G

Question

Given the following molecules and their pKa values, answer the following and briefly explain your answer:

Ibuprofen, pKa = 4.45

3,4-Methylenedioxymethamphetamine (MDMA) pKa = 10.1

a. Do you expect these molecules to be protonated or deprotonated in the stomach?

b. Will these molecules be neutral, positively charged, or negatively charged in the stomach?

c. Will these molecules be readily absorbed from the stomach?

d. Do you expect these molecules to be protonated or deprotonated in the blood stream?

e. Will these molecules be neutral, positively charged, or negatively charged in the blood stream?

f. Will these molecules be readily absorbed from the blood stream?

Given the following molecules and their pKa values, answer the following and bri

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