Which of the following statements are true if the particle size in a packed colu

Question

Which of the following statements are true if the particle size in a packed column used in HPLC is decreased? (check all possible)

(a) Increased separation efficiency

(b) Requires a higher operating pressure

(c) Decreased operating temperatures

(d) Longer analysis times

(e) Allows the use of a lower operating pressure

Hints: A smaller particle size reduces the distance a solute molecule must travel to interact with the stationary phase. However, it is more difficult for the mobile phase to pass through the column at lower pressures.

Explanation / Answer

true

(a)

(b)

(d)

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