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Adenosine monophosphate (AMP) is a regulatory molecule in metabolic processes su

ID: 927717 • Letter: A

Question

Adenosine monophosphate (AMP) is a regulatory molecule in metabolic processes such as glycolysis and gluconeogenesis. For example, it stimulates the glycolytic enzyme phosphofructokinase, and therefore ATP production, and it inhibits the gluconeogenic enzyme fructose 1,6-bisphosphatase. Adenylate kinase catalyzes the reversible reaction shown here: During periods of intense activity, when glycolysis is used in the generation of ATP, the reaction lies to the right, decreasing [ADP], generating ATP, and accumulating AMP. However, [ATP] is usually much greater than [ADP], and [ADP] is greater than [AMP]. Determine [AMP] when 5% of the ATP in a hypothetical cell is hydrolyzed to ADP. In this cell, the initial concentration of ATP is 269 ¿/M, and the total adenine nucleotide concentration (the concentration of ATP, ADP, and AMP) is 382 JJM. The equilibrium constant Kis 0.82 What is the concentration of AMP after 5% of the ATP is hydrolyzed to ADP?

Explanation / Answer

Adenosine monophosphate (AMP) is a regulatory molecule in metabolic processes su

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