QUESTION 16 Which of the following is not a potential problem with somatic cell
ID: 93735 • Letter: Q
Question
QUESTION 16
Which of the following is not a potential problem with somatic cell gene therapy?
Transient expression
Potential for oncogenesis as a result of random integration
Difficulties in regulating gene activity
Ethical concerns surrounding the permanent alteration of our genetic heritage
None of the above
Transient expression
Potential for oncogenesis as a result of random integration
Difficulties in regulating gene activity
Ethical concerns surrounding the permanent alteration of our genetic heritage
None of the above
Explanation / Answer
Answer:
Q: Which of the following is not a potential problem with somatic cell gene therapy?
Explanation: Somatic gene therapy affects the patient only and is not inherited by the next generation unlike Germline gene therapy which contributes to the genetic heritage of the offspring. This is because in somatic gene therapy cells other than the germ cells, gamete or stemcells (undifferentiated) are used for the transfer of therapeutic genes. On the other hand, in germline gene therapy defective genes in the germline cells are replaced and therefore it can be transferred to the offspring.
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