What is the pattern of inheritance of the above pedigree?78 Based on the pattern
ID: 96243 • Letter: W
Question
What is the pattern of inheritance of the above pedigree?78 Based on the pattern of inheritance, the disease is most likely on which type of the human chromosome 79 name a human disease that follows the above pattern of inheritance 80 How many diseases carriers in the pedigree? 81 How many generations are in the disease pedigree? 82 How many unaffected with the diseases 83 how many individuals do not have the disease alleles? 84 -The disease alleles that result in expression of the disease phenotype in the in the affected individuals originate from whom in the pedigree? 85 How many individuals married into the family in the disease pedigree? 86 The three Mendel's laws of inheritance are 1) 87 2) 88, and 3) 89. Can incomplete penetrant occur with this pedigree 90. A. Autosomal dominant B. None Mendelian C. Maternal inheritance D. Paternal inheritance E. Autosomal recessive A. Autosomal chromosome B. X chromosome C. Sex chromosome D. Y chromosome E. Mitochondria chromosome A. Maternal B. Tay-Sachs C.DMD D. None Mendelian E.DM A. 12 B.11 C.10 D. 9 E.4. A. 6 B.8 C.3. D.5 E.4 A. 32 B.30 C.28 D.27 E.31 A. 18 B. 20 C.21 D.23 E.33 A. I-2 and I1-2 B. II-2 and I-1 C. I-2 and II-2 D.I-1 and 11-1 E.I-2 and 11-1 A. 5 B.4 C.3 D.6 E.7 A. Law of Mendelian B Law of unit of inheritance C. Law of hereditary D. Law of unit of Ascertainment E. Mendel Pattern of Inheritance A. Law of Mendelian B. Law of segregation C. Law of hereditaryExplanation / Answer
The above pattern is autosomal recessive. That is because in the given pedigree, if we take autosome chromosome as AA and aa where A is dominant and a is recessive, then for an example:
From Ist generation:
Male AA x Female Aa
Progeny would be AA and Aa but both male and female would be affected.
Now the cross is autosomal because in the cross between III-5 and III-6 has produced male and female both progenies ill (IV-5 and IV-6). That is because Y linked trait would not deliver in female progeny and X linked trait of father would not deliver to his son. The trait is recessive because some progenies are carrier only and the diseased progeny would occur if both alleles were present.
Therefore, for filling 78- E is correct, for 79- A, for 80- B tay sachs is known for autosomal recessive. The black and white rounds are carriers; therefore, 81-B is correct. Disease generations are all four generations. the unaffected persons are those who neither carrier nor diseased. Individual do not have disease alleles include those who are carriers too because they are not diseased. The disease allele has originated from I-2 and II-1 individuals.
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