Serine proteases stabilize the transition state in order to effectively increase

Question

Serine proteases stabilize the transition state in order to effectively increase the rate of the reaction. Which panel represents the transition state?

Panel A (Enzyme-substrate complex)

Panel B (Tetrahedral intermediate)

Panel C (Acyl-enzyme intermediate)

Panel D

Panel F (Active enzyme)

A.

Panel A (Enzyme-substrate complex)

B.

Panel B (Tetrahedral intermediate)

C.

Panel C (Acyl-enzyme intermediate)

D.

Panel D

E.

Panel F (Active enzyme)

Asp 102 His 57 Asp 102 57 CH2 CH2 Ser 195 Ser 195 N 1 CH2 CH2 Nucleophilic attack R' Substrate/ polypeptide N Tetrahedral intermediate Enzyme-substrate complex Asp 102 57 Asp 102 His 57 CH2 Ser 195 CH2 Ser 195 H20 N 1 CH2 CH2 New N-terminus of R cleaved polypeptide R chain R'NH2 N C 0 Acyl-enzyme intermediate Asp 102 His 57 Asp 102 His 57 CH2 Ser 195 CH2 Ser 195 CH2 CH2 New C-terminus of cleaved polypeptide/R chain Tetrahedral intermediate Active enzyme © 2008 John Wiley & Sons, Inc. All rights reserved.

Explanation / Answer

b ) Panel B ( Tetrahedral intermediate)

Serine proteases preferentially bind the transition state and the overall structure is tetrahedral and this couse lowering the activation energy of the reaction.

Related Questions

Navigate

• Browse (All)
• Browse S
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.