Glycolysis produces NADH. However, NADH cannot cross the inner mitochondrial mem

Question

Glycolysis produces NADH. However, NADH cannot cross the inner mitochondrial membrane to be used in the electron transport chain (respiratory chain). The malate-aspartate shuttle in some animal cells transfers electrons from cytosolic NADH to the matrix. A diagram of the malate-aspartate shuttle is given below. You can use it as a reference to answer parts (a) and () a) Which compound accepts electrons from NADH, producing a compound that can pass through the inner membrane? b) Which compound transfers reducing equivalents (electrons) into the mitochondrial matrix? O malate O-ketoglutarate O oxaloacetate O glutamate O aspartate O glutamate O aspartate ketoglutarate oxaloacetate

Explanation / Answer

The net effect of the malate-aspartate shuttle is purely redox: NADH in the cytosol is oxidized to NAD+, and NAD+ in the matrix is reduced to NADH. The NAD+ in the cytosol can then be reduced again by another round of glycolysis, and the NADH in the matrix can be used to pass electrons to the electron transport chain so ATP can be synthesized.

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