Use the following diagram from a Nature Review article that outlines +RNA viral

Question

Use the following diagram from a Nature Review article that outlines +RNA viral replication to help you answer the activity questions on the next page.

4. Over on the upper right side of the figure, labeled “B”, why does the virus shut off host cell translation and transcription? What is the benefit of this to the virus?

Pro-apoptotic Anti-apoptotic ffocts Shut off host cell Shut off host cell (cap Polyprotein nteractions between the vinus and the cel cycle ral replication complex dsRNA (atency) strand (goniome 3 3 5 3 Cell lysis Veal ogrees Nature Reviews Microbiology 3, 765-776 (October 2005) dol: 10.1038/nrmicro1284

Explanation / Answer

To increase the viral gene expression in the cells. If host cell gene is expressed lot of proteins and mRNA are produced by the host it interfer with viral replication also some proteins are expressed to show that cells are infected with virus. This proteins then expressed in outer plasma membrane to give signals to immunological cells and alert them.

So, to increase the viral replication and escape from the immune system it uses the inhibition of transcription and translation of host cells..

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