You are taking a final exam but you have a terrible headache and you plan to tak

Question

You are taking a final exam but you have a terrible headache and you plan to take a pain reliever. Coincidentally, the pharmacokinetic information of the same pain reliever is given in one of the questions: Elimination rate constant = 0.3 h-1; Absorption rate constant = 6 h-1; Apparent volume of distribution = 35 L; Fraction absorbed = 80%; Therapeutic range = 10-20 g/ml. What dose (in mg) should you take? When you will you get maximum relief? At what time should you think about taking another dose? How much should you take for the second dose?

Explanation / Answer

The linear sequence of amino acids forms the primary structure of proteins (Fig. 3-6). Some portions of many proteins have asecondary structure in the form of an alpha helix in which the carbonyl group (C = O) next to one peptide bond forms a hydrogen bond with an imino group (NH) flanking a peptide bond a few amino acids further along the polypeptide chain. The protein chain may fold back upon itself, forming weak internal bonds (e.g., hydrogen bonds, ionic bonds) as well as strong covalent disulfide bonds that stabilize its tertiary structure into a precisely and often intricately folded pattern. Two or more tertiary structures may unite into a functional quaternary structure. For example, hemoglobin consists of four polypeptide chains (two identical -chains and two identical -chains). A protein cannot function until it has assumed its full tertiary or quaternary configuration. Any disturbance of its normal configuration may inactivate the function of the protein. For example, if the protein is an enzyme, heating may destroy its catalytic activity

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