Make the bacteria produce A at a lower rate and in smaller amounts b) Dissolve t

Question

Make the bacteria produce A at a lower rate and in smaller amounts b) Dissolve the protein aggregate in urea, dilute and remove the urea c) Treat the insoluble aggregate with a protease. Make the bacteria produce chaperone proteins in addition to A. Using the aa sequence supplied below, a) calculate the # turns formed by the resultant alpha-helix. b) indicate which aa will be oriented towards the exterior surface of this intracellular peptide. Why? Gly-Leu-Asp-Glu-lle-Ala-lYS-Ser-Va-Arg-His-Phe-Cys-His-Ala-lle-Ala Met Tyr Ser-Gly-Glu For the schematic diagram of a protein shown below, label the three protein strands that are linked together as a beta-pleated sheet as "b" and using arrows indicate and state whether they are parallel or antiparallel.

Explanation / Answer

2)

a) One turn contains 3.6 residues. The given sequence contains 22 amino acid residues. Therefore, the given helix contains 6 full turns.

b) Polar amino acids will be oriented towards the exterior surface of any intracellular peptide. This is because of the presence of hydrophobic core. The polar amino acids are serine, threonine, asparagine, glutamine, histidine and tyrosine.

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