The DNA sequence of a portion of gene in a wild-type organism is TTACCATATTCACCC

Question

The DNA sequence of a portion of gene in a wild-type organism is TTACCATATTCACCC, and the corresponding peptide sequence is Leu-Pro-Tyr-Ser-Pro. The corresponding gene fragment in phenotypic variant of the organism is TTATTATATTCACCC and the peptide sequence is Leu-Leu-Tyr-Ser-Pro. This is an example of a ________ mutation (type) resulting in a ________ mutation (effect). Choose one of the following answers below.

d) substitution : missense

a) base substitution : nonsense ib) insertion : nonsense c) deletion : missense

d) substitution : missense

e) base substitution : silent

Explanation / Answer

The answer is D. Substitution : Missense.

TTA CCA TAT TCA CCC
TTA TTA TAT TCA CCC

The first two nucleotides in second codon that is the C is substitued with T. It is an example for sustitution muations.

The orignal peptide is Leu-Pro-Tyr-Ser-Pro and the mutant peptide is Leu-Leu-Tyr-Ser-Pro. The Pro changed in to Leu. It is an example for missence mutation.

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