A mixture containing the compounds below was separated by normal-phase thin-laye
ID: 1063754 • Letter: A
Question
A mixture containing the compounds below was separated by normal-phase thin-layer chromatography, using silica gel as a stationary phase and a 1:1 mixture of hexane and ethyl acetate as the mobile phase. Rank the molecules below order of decreasing Rf under these conditions. In "Resolution of Enantiomers" lab, you start with a pair of enantiomers Explain what experimental method is used to separate them and why this works. Could TLC or a chromatographic column be used to separate enantiomers? 2-Methyl-2-propanol (12.7mL; d = 0.79 g/ml) was reacted with 30.0ml of concentrated hydrochloric acid A total of 10.8 grams of pure 2-chloro-2methylpropane was obtained from the reaction. Complete the following: (C=12, H=1, O=16, Cl=35) Write the structural equation of this reaction. What is the theoretical yield of this reaction?Explanation / Answer
at the base wil be the most polar compound and at the top will be the most non polar compound
as we know that TLC is based on the basis of adsorption and on the basis of like dissolved like...
the order will be
K > M>N>L>P
the more the distsnce moved by the solute ..more will be the Rf
2) enantiomers can not be separated by TLC as they have same physical properties except that they rotate plane polarised light in opposite direction and same chemical properties except when they react with another chiral molecule.
with this i have indirecftky given youthe hint ....
so let's come to the actual process of separation ... to separate a chiral molecule we need to react it with another chiral molecule and the mixture of products formed ...then can be separated easily .
eg
(R/S)acid + R-alcohol ---> R,S - ester + R,R ester
the products noe become a diastereomers and can ne separated by distilation.
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