9. A drug that does not dissociate has a molecular weight of 300. If 300 g of th
ID: 1076387 • Letter: 9
Question
9. A drug that does not dissociate has a molecular weight of 300. If 300 g of this drug are dissolved in 1000 ml of water, what is the osmolarity (in Osmols/iter or mosmols/liter) of the resulting solution? 10. Compared to human plasma, the above solution will be a. iso-osmotic for man b. hyper-osmotic c. hypo-osmotic 11. A drug has a molec. weight of 200. How many grams would you use to make 100 ml of a solution that is isotonic (for man)? Assume that the diluent is distilled water and that the drug does not ionize in water 12. Percent-solutions are made on the basis of g/ml or m/ml of diluent, and it is usually assumed that 1 ml of water 1 g of water. For example, 20 g/100 ml of water or 200 g/1000 ml of water = a 20 % solution. If a 60 % solution of a substance (molec. wt. of 150) is infused intravenously (i.v.) into a patient, what will happen to the red blood cells at the site of infusion? Explain your answer in terms of the osmolarity of the solution. Assume that the substance does not ionize.Explanation / Answer
Ans 9 :
Since the drug does not dissociate , the molarity and osmolarity of the drug becomes same.
Number of osmoles = given mass / molecular weight
= 300 / 300
= 1 osmol
Osmolarity = Number of osmoles / volume of solution in L
= 1 / 1
= 1 osmols /liter
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