Your patient has a disease caused by a problem with a crucial enzyme. This enzym
ID: 11364 • Letter: Y
Question
Your patient has a disease caused by a problem with a crucial enzyme. This enzyme is normally made of 4 subunits, and each of these folded peptide chain subunits is roughly 40 amino-acids long.As part of a team of doctors, you are trying to figure out the cause of this disease. Your co-doctor decides that because this is a multi-part enzyme the problem cannot have anything to do with hydrogen bonding. They decide that it must be due to some problem with ionic, hydrophobic, or disulfide bonding between the subunits.
You disagree with your colleague. Give 2-3 reasons or hypotheses for how hydrogen bonding may be important to his disease.
(Each can be a sentence or less, feel free to write more if you think it needs more explanation)
Explanation / Answer
Your patient has a disease caused by a problem with a crucial enzyme. This enzyme is normally made of 4 subunits, and each of these folded peptide chain subunits is roughly 40 amino-acids long. As part of a team of doctors, you are trying to figure out the cause of this disease. Your co-doctor decides that because this is a multi-part enzyme the problem cannot have anything to do with hydrogen bonding. They decide that it must be due to some problem with ionic, hydrophobic, or disulfide bonding between the subunits. You disagree with your colleague. Give 2-3 reasons or hypotheses for how hydrogen bonding may be important to his disease. 1. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrills formed by misfolded proteins. The misfolding is caused by incorrect hydrogen bonds in the secondary protein structure. These secondary structures are defined by patterns of hydrogen bonds between the main-chain peptide groups. 2. Aggregated proteins are associated with prion-related illnesses such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy (mad cow disease), amyloid-related illnesses such as Alzheimer's disease and familial amyloid cardiomyopathy or polyneuropathy, as well as intracytoplasmic aggregation diseases such as Huntington's and Parkinson's disease
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