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NOMED O e immunelegy an antibosty mediated hypersenaitivity disease where the ta

ID: 126305 • Letter: N

Question

NOMED O e immunelegy an antibosty mediated hypersenaitivity disease where the target is ain extracellu expeeted disease outeome would be Develywnent of a generalicest skin rh Cpolusion of blood vessele trougthout the body due to deposition ef la matris protein expressed only in the kidney Fenver ant boxe shook dive to aystemie cvtakinve release Nation of the kidney oaused by complement activation immune oomplexes ss. Which of the following is NOT an examples of a T eell mediated hypersensitivity reaction? A Anaphylavis oocurring within minutes of eating shelifish C Destruction of panoreatic islet cells in typel diabetes Development of a rash on the shin following contact with poison ivy The development of a raised wheal 72 hours after exposure to tuberouln toxin in a Mantoux test D. 3& Adoptive cell therapy for the treatment of cancer involves taking the patient's own T cells, expanding and activating them in vitro, before re- injecting them. Which of the following potential problems will NOT be an issue for the patient? A. The patient may not have any T cells that are specific to the cancer B. The patient's tumoun-specific T cells might have all been anergised C. The transfermed T cells may not migrate to the tumour in sufficient numbers to be effective The patient may develop graft versus host disease as a result of the cell transfer D. 35. Which of the following immune mechanisms is most likely to be involved in the acute rejection of an allogeneic skin graft? A. Recipient CD4 T cells recognising donor MHC molecules and secreting B. Recipient antibodies binding to donor alloantigens and activating C. Donor Langerhan's cells migrating out of the graft and activating D. Donor CDS T cells recognising recipient MHC and causing GVHD cytokines alloreactive CDS T cells in the lymph nodes

Explanation / Answer

In question number 32

Answer D there will be deposition of antibody-antigen immune complexes in tissues.

In Q.32

Answer is C there will be no any case of destruction of pancreatic islet cells

As all the symptoms are quite obvious as food allergy with eating shellfish, development of raised wheal (a discrete, pale elevation of the skin) in Mauntoux test

In question 33, answer is A, as other issues are not desired in this case, for offering effective therapy.

In question 34

Answer is A, as there is it involves CD4+ and CD8+ T cells recognizing whole donor MHC class II and I molecules, respectively.

Furthermore this class of antigen recognition induces a vigorous polyclonal T-cell response.