ATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Ma. Gonzalex and the team look

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ATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Ma. Gonzalex and the team look over the resules from Tristan's bloodwork and discuss the possible outcomes. The extended PTT valaes, combined with the elevated platelets, make the team decide to call in the local hematology oncolorgy spocialis. Upon viewing the resuls the hemastologist requests a factor VIl ssay. Again you are curious as to what a factor VIII test is, and De. Johnson explains CIEN Factor VW Assay This is a blood test that measures the activity of factor VIIl. Factor VIIl or factor 8 is a large procein that is important to the clotting cascade. It accelerases the activation of factor X. Factoe VIII is not an enzyme, but it plays a large role in the activation of factor X. The factor VIII assay measures the percentage of factor VII pecsent in the blood. Resuls are represented as a percentage of factor VIII neoded to from a clot. Normal levels range from 50-200%. When esults are kn this test can be used to diagnose hemophilia A. Vie Willebrand's disease, and presence of factor VIII inhibitor (an antibody. For hemophilia A, levels less than 1% constitute severe hemophilia, l-5% signifies moderate bemophilia and values of 6-49% are diagnostic of mild hemophilia. When values are too high, this test can be used to diagnoselas a marker for diabetes, liver disease, inflammation, obesity, or pregnancy Results from Tristan's test are listed below Factor Vill Assay Results-T.Hunter Value Normal 0.27% Measure Factor VIllI Questions 6. What is factor VIIIP Why would having a decreased/absent amount of factor VII be problematic 7. What can an abnormal factor VIII test result mean? Do any of these conditions overlap with the possible outcomes from the PTT test? Based on the combined results, what is the most likely diagnosis?

Explanation / Answer

6.Factor VIII is known as anti-haemophillic factor.

This factor plays an important role in activating the Cascade.

Absence of this factor can be a cause of X linked recessive disorder called haemophilia A.

This factor helps in clotting of blood. If factor is absent or present in less amount then blood will not be able to clot.

7. Abnormal level of factor VII correlate with the presence of a disease called haemophilia A .

If value of PTT is also less then it will confirm that the person is suffering from haemophilia A.

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