6. Pedigree analysis (7 pts.) For each of the pedigrees, explain why each of the

Question

6. Pedigree analysis (7 pts.) For each of the pedigrees, explain why each of the possible inheritance patterns may be possible or may not be possible. For example, you could say, "The trait in pedigree I could not be Y-linked because the female in the top row exhibits the trait and does not have a Y chromosomes." The inheritance patterns to consider for both pedigrees are autosomal dominant, autosomal recessive, X- linked dominant, X-linked recessive, Y-linked dominant, Y-linked recessive, and mitochondrial inheritance. You should use specific examples to support your arguments Pedigree I Pedigree II

Explanation / Answer

Pedigree 1: The inheritance is autosomal dominant. This is because both males and females are equally affected which rules out any sex linked inheritance. Further, there is no alternation of generations in the affected trait. Half of the offsprings are affected in each generations. All of these point towards autosomal dominant mode of inheritance.

Pedigree 2: This shows autosomal recessive mode of inheritance. Both males and females are equally affected which rules out sex linked inheritance. Further, normal parents have affected offsprings which rules out autosomal dominant inheritance. So, the in inheritance here is autosomal recessive.

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