The following questions are to be completed ih small groups during the tutorial

Question

The following questions are to be completed ih small groups during the tutorial session A small number of type O individuals have the Bombay blood phenotype. Individuals with the Bombay blood phenotype always appear to have type O blood because they are homozygous recessive for the gene, H, which is epistatic to gene I. As long as at least one dominant H allele is present, the ABO blood type associated with the person's ABO genotype will be expressed. Individuals who are homozygous hh always have type O blood. The pedigree below includes two individuals with the Bombay blood phenotype AB AB B o Use the above information to answer the next two questions. 1) The possible genotypes of 1-2 are: 2) What is a possible genotype for ll-1? c) ii hh e) A hh

Explanation / Answer

1) As in the second generation, two individuals are present with Bombay phenotype with hh allelic conditions, they have to get one h allele from mother and one h allele from father. So both of the parents have to contain one h allele each.

And I-2 parent has to contain one IO allele to give rise to II-3, B blood group containing individual.

So the genotype of I-2 is IA/IO Hh.

2) II-1 individual has Bombay phenotype, so he has to contain hh alleles. Besides this he can get IA or IB from father and IA or IO from mother.

So one possible genotype of II-1 is- e) IAIA hh

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