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Did the number of transporters in DKO vs WT explain the change in absorption? Tr

ID: 148038 • Letter: D

Question

Did the number of transporters in DKO vs WT explain the change in absorption?

Transport kinetics determines the rate of transport. We talked about three conditions that change kinetics. 3, Did the rate at which the transporters change conformation in DKO vs WT explain the change in absorption?

No, as the transporters are not expressed at lower levels, this cannot explain the decrease in absorption of nutrients C FFAs absorption ralated genes expression 5 D B Expression of amino acid transporters Bile acid transporter expression 250 x 200 150 DKO 15 O WT D100 DKO 15 0

Explanation / Answer

1. Yes, an increase in the expression of the free fatty acid transporter, FATP4, explains the increase in free fatty acid absorption in DKO mice

2. Yes, the data show that the transporters in DKO mice increased their rate of activity.

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