Application 3. Imagine a whole string of voltage-gated sodium channels lined up

Question

Application 3. Imagine a whole string of voltage-gated sodium channels lined up in a row on a membrane. As the first one reaches threshold and opens, what will happen to the voltage of the cell near that channel? a. What will that do to the voltage-gated Na channel next to it? b. What will that do to the voltage-gated Na channel next to that one? (Do you see a pattern here?) Model 2: Action Potential 20 Threshold (-59 mv) .60 80 100 Tame (sec) Localized depolarization (enough stimulus-gated channels activated to reach threshold) Localized depolarization activated, but not enough to reach threshold) Critical Thinking Questions 4. According to the model, what causes localized depolarization that doesn't result in the cell reaching threshold? a. Do you think that the nerve cell is actively conducting a signal when these events occur?

Explanation / Answer

Answer

3)

A) when the first one voltage gated sodium channel reaches the threshold, the channel will get opened and there will be rapid influx of Na inside the membrane. As a result outside of membrane sill become negative and inside positive. But the voltage gated sodium channel next it is still closed with positivity outside and negativity inside. As a result of electrical differences between the adjacent side, local circuit current generates which take the RMP of that site toward threshold resulting in opening of that voltage gated sodium channel.

b) This process continues one after the other in row and all the voltage sodium channel gets opened.

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