The drug MTDIA is used to target the MTAP enzyme. A group treated with MTDIA sho

Question

The drug MTDIA is used to target the MTAP enzyme. A group treated with MTDIA showed an accumulation of MTA in both the A549 and H358 cancer cell lines. Why was there an accumulation of MTA when treated with MTDIA? I'm a bit confused with whether MTA is good or bad in cells. Why use a drug if MTA increases, when the purpose of the MTAP enzyme is to prevent the accumulation of MTA?

Also A549 and H358 treated with MTDIA showed a decrease in spermidine/spermine synthesis levels. Is this due to the increase in MTA inhibiting the product of polyamine biosynthesis?

Explanation / Answer

The drug is used in the treatment of human non-small cell lung carcinoma and human bronchioalveolar non-small cell lung carcinoma. The accumulation is because it is effective in treating both the above mentioned conditions. Also MTA levels in blood, urine increases due to MTDIA treatment.

Related Questions

Navigate

• Browse (All)
• Browse T
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.