Researchers investigated the long term impact of non alcoholic fatty liver disea

Question

Researchers investigated the long term impact of non alcoholic fatty liver disease (NAFLD) in terms of mortality utilizing data from The Nation Health and Nutrition Examination Survey (1988-1994). They compared mortality rates (median 14.5 year follow-up) among those with advanced fibrosis to those without fibrosis. They reported HR=1.69 (95% Cl 1.09-2.63) What does this result indicate about the risk of mortality for NAFLD patients with advanced fibrosis compared to NAFLD patients with fibrosis?

a. There is no difference in risk of mortality within 14.5 years between those with advanced fibrosis and those without fibrosis

b. There is a greater risk of mortality within 14.5 years for those without fibrosis compared to those with advanced fibrosis

c. Those with advanced fibrosis have a greater risk of mortality within 14.5 years then those without fibrosis

Explanation / Answer

Ans C:- Those with advanced fibrosis have a greater risk of mortality within 14.5years than those without fibrosis.

HR is the hazard ratio calculation is a complex statistical   analysis.

The value given here is 1.69 and the hazard ratio in its simplest form is the event occurring in the study subjects in compared to events occurring in the control subject groups. So higher the value greater will be the events in the study subjects. They are giving the results with 95% confidence interval. That means 95% chances are there that the value always fall in the given range.

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