Your patient was a Harry Belafonte fan who was fascinated by the reference or \"
ID: 175131 • Letter: Y
Question
Your patient was a Harry Belafonte fan who was fascinated by the reference or "akee rice" in the song "Jamaica Fare well" and went to spend his vacation in Jamaica, gorging himself on cooked ackee fruit. When he returned, he smuggled some unripe ace fruit through customs and then ate some for lunch. The next day he was admitted to the hospital with severe vomiting and he expired shortly after telling you about his vacation. Analysis of his urine showed high levels of glutamic acid and 2-ethylmalonic acid. You obtain mitochondria from the liver cells and sonicate them (break them up into little fragments). You treat them with dichlorophenol indophenol (DCIP), an electron acceptor dye that changes color when it accepts an electron. You add NADH and find that the DCIP changes color as much as occurs in a mitochondrial preparation from a normal person. However, when you add glut aryl-CoA or palmityl-CoA, you find that the DCIP does not change color. Research in the library reveals that unripe ackee fruit contains hypoglycemic A, which our bodies metabolize to methyl recycle propyl acetyl-CoA. What enzyme(s) do you think is/are inhibited by methylenecyclopropane propyl acetyl-CoA? If you were doing research on this disease, for example in an animal model, would you consider testing the therapeutic effect of riboflavin? Why, or why not?Explanation / Answer
1. The disease which occurs due to consumption of unripe ackee tree fruit is called jamaican vomiting sickness. It s caused because the hypoglycin A, an inhibitor is released. Inactivation of several acyl-CoA dehydrogenase occurs by toxic metabolite hypoglycinA from unripe ackee tree. Short chain acyl CoA, medium chain acyl CoA, isovaleryl CoAdehydrogenases are severly imactivated.
2. The riboflavin is thought to antagonize the toxic effect of the hypogylcin A. The riboflavin stimulates the de novo synthesis acyl CoA dehydrogenase which reverses the effect of the disease.
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