Hemophilia A is an X-linked recessive disorder characterized by lack of a functi

Question

Hemophilia A is an X-linked recessive disorder characterized by lack of a functional Factor VIII, a protein involved in blood clotting. In one population, the frequency of the normal allele, X 1, is 0.98 and the frequency of the mutant allele that causes hemophilia A, X 2, is 0.02. What percentage of males in this population have hemophilia A?

Assume that the population described in Part A is in Hardy-Weinberg equilibrium.

What is the frequency of females who have hemophilia A in this population?

Explanation / Answer

Haemphilia A is an X-linked recessive disorder that is passed from mother to son.

From the given data,

The frequency of normal allele X1 = 0.98

Frequency of mutant allele X2 = 0.02

According to the Hardy-Weinberg equillibrium

p2 + 2pq + q2 = 1

(0.98) + 2(0.98)(0.02) + (0.02)

= 0.98 + 0.039 + 0.02

= 1.039

The homozygous affected male (q) = 0.02 * 100 = 2%

The heterozygous carriers (2pq) = 0.039 * 100 = 3.9%

The homozygous unaffected individulas = 0.98 * 100 = 98%

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