When placed in a strongly acidic solution, a protein\'s acidic side chains will

Question

When placed in a strongly acidic solution, a protein's acidic side chains will be and the basic side chains will be When placed in a strongly basic solution, a protein's acidic side chains will be and the basic chains will be In a strongly acidic solution, the overall charge of normal beta globin is (magnitude and charge) In a strongly basic solution, the overall charge of normal beta globin is (magnitude and charge) In HbS (sickle cell hemoglobin), each beta globin subunit has a missense mutation described as E6V. What does "E6V" mean? [You should know: The initial methionine is trimmed off, and the adjacent valine is thus considered the first amino acid.]

Explanation / Answer

When placed in a strongly acidic solution, prrotein's acidic side chains (-COO) get protonated or cationic and basic side chain is neutral,

When placed in strongly basic solution, protein's acidic side chain remains neutral , basic chain (NH3+) gets deprotonated

Therefore

In strongly acidic solution, chrarge of beta globin gene is positive

In strongly basic solution charge of beta globin is negative

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