Albinism is a condition in humans in which affected individuals are unable to pr
ID: 176036 • Letter: A
Question
Albinism is a condition in humans in which affected individuals are unable to produce the pigment melanin. People with this condition take on the color of the blood flowing through their capillaries. This occurs when the dominant allele is absent and an individual gets two defective recessive alleles. What phenotype would an individual have that has the genotype homozygous "normal?" What phenotype would an individual have that has the genotype heterozygous? A man heterozygous for albinism has 4 children with an albino woman. What phenotypic and genotypic ratios would you expect A couple that both have "normal" skin color has an albino child and 2 "normal" children. What are the parents' genotypes? What are the chances of a couple, both hybrid for albinism, for having 3 "normal" children?Explanation / Answer
QUESTION1
What ….homozygous normal
Genotype----AA
QUESTION2
What ….heterozygous normal
Genotype----Aa carrier
MAN------heterozygous ------ Genotype----Aa --- carrier
WOMAN------ homozygous ------ Genotype----aa --- affected
Genotype----Aa x Genotype----aa
A
a
a
Aa normal
aa affected
a
Aa normal
aa affected
Chance of getting affected offspring = ½
P=1/2
Q=1/2
N=4 CHILDREN
(P+Q)^4 = (p + q)4 = p4 + 4p3q + 6p2q2 + 4pq3 + q4
FREQUENCY
FREQUENCY
P^4
ALL NORMAL
(0.5)^4
0.0625
4p^3q
3 (NORMAL) :1(AFFECTED)
4 (0.5)^3 (0.5)
0.25
6p^2q^2
2 (NORMAL) :2(AFFECTED)
6(0.5)^2(0.5)^2
0.375
4pq^3
1(NORMAL) :3(AFFECTED)
4(0.5) (0.5)^3
0.25
q^4
ALL AFFECTED
(0.5)^^4
0.0625
=============
QUESTION 5
Genotype----Aa x Genotype----Aa
A
a
A
AA normal
Aa normal
a
Aa normal
aa affected
ANSWER =3/4 = 0.75
QUESTION1
What ….homozygous normal
Genotype----AA
QUESTION2
What ….heterozygous normal
Genotype----Aa carrier
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