HELP ANSWERING THIS QUESTIONS PLEASE. (I did part of one already) 1. What type/c
ID: 176489 • Letter: H
Question
HELP ANSWERING THIS QUESTIONS PLEASE. (I did part of one already)
1. What type/class of protein is involved in your disease? Is it an enzyme, a transporter, an ion channel, etc? Try to generalize its function if you can’t find anything explicit. (Hint: if its name ends in –ase, it’s an enzyme)
-Answer -The protein that is affected by Gaucher’s Disease is the Beta-Glucocerebrosidase protein. This protein is an enzyme responsible for breaking down a fatty acid called glucocerebrosidase into glucose and ceramide. (MORE)
2. Protein Interactions:
a) What types of molecules does your protein interact with? If it’s an enzyme, what does it put together or take apart? If not an enzyme, what molecules does it interact with? Does your protein interact with any other proteins? List those as well
b) What are the important factors in a protein being able to interact with the molecule it does? Why would two proteins or two molecules ever come together in water?
c) How do you think your protein interacts with the molecule it does?
3) What do these molecules that your protein interacts with do in/for the cell?
4) Is your protein influencing any specific cellular process? (i.e. Transcription, translation, metabolism, etc.)
5) If your protein is an enzyme that breaks things down, would that molecule still get broken down? Where would those extra unprocessed molecules go and what could they do?
6) Try to think about what organs in your body would be involved, and what they do. Would a mutation in this protein affect them by causing something to happen, or by causing something to not happen?
7) If your protein were to stop working, what kind of symptoms do you think that would cause?
Explanation / Answer
2. Protien glucocerebrosidase reacts with sphingolipids(Glucocerebroside) Which is a cellmenbrane constituent of RBC and WBC.
3.Two proteins or molecule come together in water because of high affinity of bond formations like hydrogen
bond,ionic bond and vandeer waals force.
4.Proteins are involved in the metabolism of sphingolipids
5.yes,protein is an enzyme invoved in the breakdown of sphingolipids.The unprocessed molecule accumulated in macrophages,spleen,liver
6.it affects the spleen and liver,enlargement of spleen liver,lymphnodes occurs,brain damage,affects eye,lungs,skeletal system
7.symptoms were heptospleenomegaly,anemia,thrompocytopenia,leucopenia,cirrhosis,osteoporesis,eye diorder,sin disease
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