Cancer Cell Biology Study sheet exam II Dec 13 1. Name 5 types of primary signal

Question

Cancer Cell Biology Study sheet exam II Dec 13
1. Name 5 types of primary signaling receptors, and describe how they work to perceive a primary signal and transduce that signal to a secondary signal. 2. Describe in as much detail as you can 3 different signaling systems that involve a protein phosphorylation step. 3. Identify how protein kinases regulate protein phosphorylation, and how protein phosphatases regulate protein phosphorylation. Give examples of each. 4. How does Wnt pathway signaling contribute to cancer? 5. What are the feature of proteins involved in the PI# kinase signal transduction pathway? 6. What are some mechanism that lead to loss of heterozygosity in tumor suppressor genes. Know a specific example for each. 7. How does NF1 mutation influence signaling by Ras protein. 8. How is the anaphase promoting complex activated and deactivated? 9. What is the role of Apc in Colon cancer? 10. 11. 2. How can p21, p53, cdc25, and ATM lead to arrest of the cell cycle? Please explain what these molecules do and how they are affected by each other. 12. What is CAK and what does it do within cell cycle regulation? 13. What is cdc25 and what does it do within cell cycle regulation 14. How does p27 CKI become part of a feedback loop within the cell cycle? 15. Describe the cyclin E & A feed-forward (positive feedback) loop within the regulation of Rb by Cdks
Cancer Cell Biology Study sheet exam II Dec 13
1. Name 5 types of primary signaling receptors, and describe how they work to perceive a primary signal and transduce that signal to a secondary signal. 2. Describe in as much detail as you can 3 different signaling systems that involve a protein phosphorylation step. 3. Identify how protein kinases regulate protein phosphorylation, and how protein phosphatases regulate protein phosphorylation. Give examples of each. 4. How does Wnt pathway signaling contribute to cancer? 5. What are the feature of proteins involved in the PI# kinase signal transduction pathway? 6. What are some mechanism that lead to loss of heterozygosity in tumor suppressor genes. Know a specific example for each. 7. How does NF1 mutation influence signaling by Ras protein. 8. How is the anaphase promoting complex activated and deactivated? 9. What is the role of Apc in Colon cancer? 10. 11. 2. How can p21, p53, cdc25, and ATM lead to arrest of the cell cycle? Please explain what these molecules do and how they are affected by each other. 12. What is CAK and what does it do within cell cycle regulation? 13. What is cdc25 and what does it do within cell cycle regulation 14. How does p27 CKI become part of a feedback loop within the cell cycle? 15. Describe the cyclin E & A feed-forward (positive feedback) loop within the regulation of Rb by Cdks
Cancer Cell Biology Study sheet exam II Dec 13
1. Name 5 types of primary signaling receptors, and describe how they work to perceive a primary signal and transduce that signal to a secondary signal. 2. Describe in as much detail as you can 3 different signaling systems that involve a protein phosphorylation step. 3. Identify how protein kinases regulate protein phosphorylation, and how protein phosphatases regulate protein phosphorylation. Give examples of each. 4. How does Wnt pathway signaling contribute to cancer? 5. What are the feature of proteins involved in the PI# kinase signal transduction pathway? 6. What are some mechanism that lead to loss of heterozygosity in tumor suppressor genes. Know a specific example for each. 7. How does NF1 mutation influence signaling by Ras protein. 8. How is the anaphase promoting complex activated and deactivated? 9. What is the role of Apc in Colon cancer? 10. 11. 2. How can p21, p53, cdc25, and ATM lead to arrest of the cell cycle? Please explain what these molecules do and how they are affected by each other. 12. What is CAK and what does it do within cell cycle regulation? 13. What is cdc25 and what does it do within cell cycle regulation 14. How does p27 CKI become part of a feedback loop within the cell cycle? 15. Describe the cyclin E & A feed-forward (positive feedback) loop within the regulation of Rb by Cdks

Explanation / Answer

1. Ion channel receptor:binds ligand and open a channel through membrane

2.Enzyme linked receptor:with intracellular domain that are associated with an enzyme

3.G protein linked receptor:

4.Intracellular receptor located in cytoplasm of cell activated by ligand that can pass through plasmamembrane

5.Cell surface receptor binds to an external ligand molecules.

4.Wnt signalling pathway are group of signal transduction pathway made of protein that pass signals into a cell through cell surface receptors this pathway is activated by Wnt protein ligands which passes signal to other protein in cell.Wnt signalling controls tissue generation abnormality leads to cancer.

8.Activation of anaphase promoting cycle is activated by the M cyclin / cdk pairs vis phosphorylation

9.APC gene is a key tumor suppressor gene.mutation in this gene causes cancer

Related Questions

Navigate

• Browse (All)
• Browse C
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.